Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease

Abstract

Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. Here, we review the concept of α-synuclein nitration and its biological consequences. We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson’s disease.

^† Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China^‡ Institute of Neuroscience, Second Military Medical University, Shanghai 200433, China

Quelle: https://pubs.acs.org/doi/abs/10.1021/acschemneuro.8b00288