Controlling the Uncontrollable
Perceptions of Balance in People With Parkinson Disease Abstract Background Exercise improves balance in Parkinson disease (PD), yet the majority of people with the… (weiter lesen)
Gut microbes eat our medication
Researchers have discovered one of the first concrete examples of how the microbiome can interfere with a drug’s intended path through the body. Focusing… (weiter lesen)
Gut Bacteria Affect Metabolism of Levodopa
Levodopa, one of the main medicines used to treat Parkinson’s symptoms, can be converted into dopamine by gut bacteria, researchers report. The findings might… (weiter lesen)
Gut bacterial tyrosine decarboxylases restrict levels of levodopa
Abstract: Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In… (weiter lesen)
Journal of Parkinson’s Disease
https://content.iospress.com/journals/journal-of-parkinsons-disease/Pre-press/Pre-press The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine… (weiter lesen)
Physical Activity and Parkinson Disease Risk
Fang et al1 reported a meta-analysis of prospective studies to determine whether there is evidence of a quantitative dose-response association between physical activity and… (weiter lesen)
A Call to Action to Improve Patient Care
Experts propose ways to address the rapidly rising number of deaths from Parkinson’s disease and related disorders and improve the end of life care… (weiter lesen)
Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease
Abstract Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known… (weiter lesen)
LRRK2 activation in idiopathic Parkinson’s disease
New proximity ligation assays were developed and validated As a LRRK2 autophosphorylation site, pSer1292 reflects the activity of LRRK2 per se. We developed a… (weiter lesen)
Neurophysiological correlates of bradykinesia
Abstract Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson’s disease. However, it is unclear whether there is… (weiter lesen)
Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation
Abstract BACKGROUND Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical… (weiter lesen)
The Role and Development of the Antagonist of Adenosine A2A
Adenosine is a neuromodulator that regulates the body’s response to dopamine and another neurotransmitter in the brain that is responsible for motoric, emotion, learning,… (weiter lesen)
Gene Therapeutic Strategies for Neuroprotection
Gene transfer methodologies are being explored as strategies to restore and preserve neuronal function in Parkinson’s Disease. This technology represents a new therapeutic modality,… (weiter lesen)
Parkinson’s Disease: A Looming Pandemic
New research shows that the number of people with Parkinson’s disease will soon grow to pandemic proportions. In a commentary appearing today in the… (weiter lesen)
Does Dopamine Trigger Movement but Not Sustain It?
The neurotransmitter dopamine sparks movement, but does not sustain it, according to a Portuguese and American study with implications for the development of Parkinson’s… (weiter lesen)
Parkinson Voice Project
Parkinson Voice Project, a nonprofit focused on speech therapy, is accepting applications for its National Grant Program that aims to assist nonprofit Parkinson’s groups and patient clinics… (weiter lesen)
Medical Cannabis Helps Older People with PD
Medical cannabis is a safe and effective way for older people to alleviate symptoms of Parkinson’s, cancer and other diseases, particularly pain, a study… (weiter lesen)
Inhaled Levodopa for ‚Off‘ Time
Acorda Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) filed its New Drug Application (NDA) for inhaled levodopa. (If approved, the… (weiter lesen)