Parkinson Stuttgart

Kategorie: Posts In English

Controlling the Uncontrollable

Perceptions of Balance in People With Parkinson Disease Abstract Background Exercise improves balance in Parkinson disease (PD), yet the majority of people with the diagnosis are physically inactive. Insights gained from understanding how… (weiter lesen)

Gut microbes eat our medication

Researchers have discovered one of the first concrete examples of how the microbiome can interfere with a drug’s intended path through the body. Focusing on levodopa (L-dopa), the primary treatment for Parkinson’s disease,… (weiter lesen)

Gut Bacteria Affect Metabolism of Levodopa

Levodopa, one of the main medicines used to treat Parkinson’s symptoms, can be converted into dopamine by gut bacteria, researchers report. The findings might explain why levodopa treatment is less effective in some… (weiter lesen)

Gut bacterial tyrosine decarboxylases restrict levels of levodopa

Abstract: Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this study, we characterize gut-associated bacteria in their ability… (weiter lesen)

Journal of Parkinson’s Disease The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our fundamental understanding and improve treatment… (weiter lesen)

Physical Activity and Parkinson Disease Risk

Fang et al1 reported a meta-analysis of prospective studies to determine whether there is evidence of a quantitative dose-response association between physical activity and Parkinson disease (PD) risk. The analysis included 8 prospective… (weiter lesen)

A Call to Action to Improve Patient Care

Experts propose ways to address the rapidly rising number of deaths from Parkinson’s disease and related disorders and improve the end of life care of Parkinson patients in JPD September 10, 2018 –… (weiter lesen)

Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease

Abstract Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein.… (weiter lesen)

LRRK2 activation in idiopathic Parkinson’s disease

New proximity ligation assays were developed and validated As a LRRK2 autophosphorylation site, pSer1292 reflects the activity of LRRK2 per se. We developed a proximity ligation assay to amplify the signal and increase… (weiter lesen)

Neurophysiological correlates of bradykinesia

Abstract Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson’s disease. However, it is unclear whether there is any relationship between them and bradykinesia, one of the… (weiter lesen)

Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation

Abstract BACKGROUND Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical practice outcomes are variable. Experienced centers are confronted with… (weiter lesen)

The Role and Development of the Antagonist of Adenosine A2A

Adenosine is a neuromodulator that regulates the body’s response to dopamine and another neurotransmitter in the brain that is responsible for motoric, emotion, learning, and memory function. Adenosine is a G-protein-coupled receptor and… (weiter lesen)

Gene Therapeutic Strategies for Neuroprotection

Gene transfer methodologies are being explored as strategies to restore and preserve neuronal function in Parkinson’s Disease. This technology represents a new therapeutic modality, holding promise for continuous and localized delivery of neuroprotective… (weiter lesen)

Parkinson’s Disease: A Looming Pandemic

New research shows that the number of people with Parkinson’s disease will soon grow to pandemic proportions.  In a commentary appearing today in the journal JAMA Neurology, University of Rochester Medical Center neurologist… (weiter lesen)

Does Dopamine Trigger Movement but Not Sustain It?

The neurotransmitter dopamine sparks movement, but does not sustain it, according to a Portuguese and American study with implications for the development of Parkinson’s therapies.

Parkinson Voice Project

Parkinson Voice Project, a nonprofit focused on speech therapy, is accepting applications for its National Grant Program that aims to assist nonprofit Parkinson’s groups and patient clinics in bringing its speech therapy approach to patients in… (weiter lesen)

Medical Cannabis Helps Older People with PD

Medical cannabis is a safe and effective way for older people to alleviate symptoms of Parkinson’s, cancer and other diseases, particularly pain, a study shows.

Inhaled Levodopa for ‚Off‘ Time

Acorda Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) filed its New Drug Application (NDA) for inhaled levodopa. (If approved, the drug will be called Inbrija.) This is the last… (weiter lesen)

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