Perceptions of Balance in People With Parkinson Disease Abstract Background Exercise improves balance in Parkinson disease (PD), yet the majority of people with the diagnosis… Weiterlesen »Controlling the Uncontrollable
Researchers have discovered one of the first concrete examples of how the microbiome can interfere with a drug’s intended path through the body. Focusing on… Weiterlesen »Gut microbes eat our medication
Levodopa, one of the main medicines used to treat Parkinson’s symptoms, can be converted into dopamine by gut bacteria, researchers report. The findings might explain… Weiterlesen »Gut Bacteria Affect Metabolism of Levodopa
Abstract: Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this… Weiterlesen »Gut bacterial tyrosine decarboxylases restrict levels of levodopa
https://content.iospress.com/journals/journal-of-parkinsons-disease/Pre-press/Pre-press The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that… Weiterlesen »Journal of Parkinson’s Disease
Fang et al1 reported a meta-analysis of prospective studies to determine whether there is evidence of a quantitative dose-response association between physical activity and Parkinson… Weiterlesen »Physical Activity and Parkinson Disease Risk
Experts propose ways to address the rapidly rising number of deaths from Parkinson’s disease and related disorders and improve the end of life care of… Weiterlesen »A Call to Action to Improve Patient Care
Abstract Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as… Weiterlesen »Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease
New proximity ligation assays were developed and validated As a LRRK2 autophosphorylation site, pSer1292 reflects the activity of LRRK2 per se. We developed a proximity… Weiterlesen »LRRK2 activation in idiopathic Parkinson’s disease
Abstract Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson’s disease. However, it is unclear whether there is any… Weiterlesen »Neurophysiological correlates of bradykinesia
Abstract BACKGROUND Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical practice… Weiterlesen »Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation
Adenosine is a neuromodulator that regulates the body’s response to dopamine and another neurotransmitter in the brain that is responsible for motoric, emotion, learning, and… Weiterlesen »The Role and Development of the Antagonist of Adenosine A2A
Gene transfer methodologies are being explored as strategies to restore and preserve neuronal function in Parkinson’s Disease. This technology represents a new therapeutic modality, holding… Weiterlesen »Gene Therapeutic Strategies for Neuroprotection
New research shows that the number of people with Parkinson’s disease will soon grow to pandemic proportions. In a commentary appearing today in the journal JAMA Neurology, University of Rochester Medical Center neurologist Ray Dorsey, M.D. and Bastiaan Bloem, M.D., Ph.D., with Radboud University Medical Center in the Netherlands, argue that the medical community must be mobilized to respond to this impending public health threat.Weiterlesen »Parkinson’s Disease: A Looming Pandemic
The neurotransmitter dopamine sparks movement, but does not sustain it, according to a Portuguese and American study with implications for the development of Parkinson’s therapies.Weiterlesen »Does Dopamine Trigger Movement but Not Sustain It?
Parkinson Voice Project, a nonprofit focused on speech therapy, is accepting applications for its National Grant Program that aims to assist nonprofit Parkinson’s groups and patient clinics in bringing its speech therapy approach to patients in their communities.Weiterlesen »Parkinson Voice Project
Medical cannabis is a safe and effective way for older people to alleviate symptoms of Parkinson’s, cancer and other diseases, particularly pain, a study shows.Weiterlesen »Medical Cannabis Helps Older People with PD
Acorda Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) filed its New Drug Application (NDA) for inhaled levodopa. (If approved, the drug will be called Inbrija.) This is the last step in the lengthy drug development and approval process. Now, the FDA reviews everything that is known about inhaled levodopa — clinical trial data, how the drug works and how it’s made. Weiterlesen »Inhaled Levodopa for ‚Off‘ Time